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One other important result was that patients treated with a single dose of prednisolone were statistically more likely to receive additional doses of the steroid compared to patients treated with 0.25 and 0.5 mg. The higher-dose group also experienced an increased likelihood of treatment failure (odds ratio [OR] increased from 1.1 [95% confidence interval [CI] = 1.05 to 1.16] to 4.9 [95% CI = 4.06 to 5.24] with 0.25 mg, from 0.7 [95% CI = 0.54 to 0.88] with 0.5 mg, and from 0.1 [95% CI = 0.02 to 0.3] (all P < 0.001) with 0.25 mg or 0.5 mg; the higher-dose group also had an increased likelihood of treatment failure (OR increased from 1.0 [95% CI = 1.00 to 1.05] to 2.0 [95% CI = 1.58 to 2.99]) with or without additional dose. The increased likelihood of treatment failure was also seen in those treated with prednisolone from a single dose (OR increased from 1.1 [95% CI = 1.04 to 1.13] to 2.0 [95% CI = 1.58 to 2.99]). CONCLUSIONS AND RELEVANCE: In patients with RA, higher prednisolone doses may be associated with an increased incidence of treatment failure, including treatment failures for steroid therapy with or without supplemental β 3 -agonists. Similar articles: